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Figure 2

From: Aguamiel concentrate from Agave salmiana and its extracted saponins attenuated obesity and hepatic steatosis and increased Akkermansia muciniphila in C57BL6 mice

Figure 2

Aguamiel concentrate and its saponins prevented obesity and glucose intolerance in C57BL6 mice.

(A) Growth curve, (B) total weight gain and (C) daily average energy intake after 12 weeks of diet-induced obesity. Animals were housed in groups (3–4 mice per cage), food intake was recorded five times per week and animal weight twice per week. (D) Retroperitoneal fat tissue weight, (E) epididymal fat tissue weight and (F) liver tissue weight normalized to total body weight after 12 weeks of diet-induced obesity. Effect of AC or its saponins on (G) the fasting glucose level, (H) OGTT and (I) glucose AUC after 10 weeks of diet-induced obesity. Data are presented as the mean ± SEM (n = 4–7). Statistical analysis was performed with one-way ANOVA followed by Tukey’s post hoc test. Treatments with different letter where a > b > c are significantly different at P < 0.05. C: control; HF: High-fat; HFAC: High-fat with aguamiel concentrate; HFL: High-fat with low saponin dose; HFH: High-fat with high saponin dose.

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