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Figure 7

From: Aguamiel concentrate from Agave salmiana and its extracted saponins attenuated obesity and hepatic steatosis and increased Akkermansia muciniphila in C57BL6 mice

Figure 7

Proposed mechanism of action of aguamiel concentrate and its extracted saponins in diet-induced obesity.

AC or its saponin extract exerted beneficial actions in metabolic tissues in mice fed a high-fat diet, thereby improving glucose tolerance and reducing adipose tissue hypertrophy and hepatic steatosis. These effects were mediated by increased WAT browning and mitochondrial activity in skeletal muscle and enhancing the abundance of Akkermansia muciniphila in the intestinal lumen. Altogether, these changes resulted in enhanced energy expenditure and preventing many metabolic complications associated with obesity.

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