Figure 7 | Scientific Reports

Figure 7

From: Pomegranate extract decreases oxidative stress and alleviates mitochondrial impairment by activating AMPK-Nrf2 in hypothalamic paraventricular nucleus of spontaneously hypertensive rats

Figure 7

Effects of pomegranate extract supplementation on the expression of mitochondrial related proteins in the hypothalamic paraventricular nucleus of control and hypertensive rats.

Control and hypertensive rats were administered either saline or pomegranate extract (150 mg/kg/day) for eight weeks, sacrificed and lysates were prepared from the paraventricular nucleus for Western blotting. (A,B) Expression levels are shown for the mitochondrial biogenesis proteins PGC-1α, Complex III and V subunits (A, Western blotting image; B, statistical analysis). (C,D) Expression levels are shown for the mitochondrial dynamics proteins, Mfn2 and Beclin1 (C, Western blotting image; D, statistical analysis). Values are the mean ± SEM from 8 animals. *p < 0.05, **p < 0.01. SHR, spontaneously hypertensive rats; PE, pomegranate extract; PVN, paraventricular nucleus; PGC-1α, proliferator-activated receptor gamma co-activator.

Back to article page