Figure 5
From: Losartan reduces ensuing chronic kidney disease and mortality after acute kidney injury
Losartan reduces mortality and ensuing CKD after severe AKI.
(a) Plasma BUN and creatinine were analyzed 14 and 27 days after IRI or sham surgery and then the mice were administered water vehicle, losartan, or hydralazine since 1 month after NX+IRI. NX only mice served as the sham control. All mice were sacrificed for analyses 5 months after surgery. N for each group at each time point was shown in (e). (b) Plasma levels of BUN and creatinine 14 days after surgery. (c) Plasma levels of BUN and creatinine 27 days after surgery. N = 32 in NX group and 39 for each group of NX+IRI in (b,c). Each symbol represents the data from each mouse. (d) Time course systolic BP. NX versus other 3 groups at 1 month; NX+IRI versus other 3 groups at 2, 3, 4 and 5 month. (e) The percentage of survival. (f) Time course urine ACR. (g) Plasma levels of BUN and creatinine at 5 month when N = 32 (NX), 27 (NX+IRI), 37 (Losartan) and 33 (Hydralazine) as shown in (e). *P < 0.05, †P < 0.01, ‡P < 0.001.
