Figure 1
Nebivolol improves cardiac function, lipid metabolism and systemic inflammatory.
(A) Representative images of cardiac sections stained with HE and WGA-FITC (nuclear staining with DAPI), scale bar = 200 μm. (B) Heart weight to body weight ratios (HW/BW; n=12). (C) Quantitative analyses of cardiomyocyte cross-sectional area (CSA). (D) Protein expression of BNP and Collagen-I. Left: representative western blot image; (E) Right: quantification of BNP and Collagen-I protein expression. (F) Echocardiographic M-mode images. (G) Heat map visualisation of the distribution of the different cytokine proteins in rat serum. In total, 10 cytokine proteins were detected by a fluorescent antibody array system: IL-1α, IL-1β, IL-2, IL-6, TNF-α, IFN-γ IFN I γ-4, IL-10, IL-13 and MCP-1. (H–Q) Each column represents values from an individual animal. Serum levels of IL-1α, IL-1β, IL-2, IL-6, TNF-α, IFN-γ, IL-4, IL-10, IL-13 and MCP-1. IL: interleukin; TNF-α: tumour necrosis factor alpha; IFN-γ: Interferon gamma; MCP-1: monocyte chemoattractant protein-1. The data are presented as means ± SEM (n = 12). *p < 0.05 vs. ND, **p < 0.01 vs. ND; #p < 0.05 vs. HFD, ##p < 0.01 vs. HFD.
