Figure 2: Spontaneous postsynaptic activity is increased in N398 DA cultures.
From: Increased nicotine response in iPSC-derived human neurons carrying the CHRNA5 N398 allele
(A,B) Spontaneous action potentials of D398 and N398 DA neurons. (C) Membrane capacitance, (D) Resting membrane potentials (RMP), (E) Input resistance of cell membrane (Rm), and (F) Spontaneous firing frequency of D398 and N398 DA neurons. (G,H) Repetitive action potentials from depolarizing current injections in D398 and N398 DA neurons. (I) Interstimulus intervals of induced action potentials of D398 and N398 DA neurons. (J,K) ICC of TH (Red) and Synapsin (Green) for D398 and N398 DA neurons. (L) Spontaneous postsynaptic currents of D398 and N398 DA neurons. (M) Frequency and amplitudes of postsynaptic current responses from D398 and N398 DA neurons.
