Figure 1: Two Monosiga Genomic Loci and Transcripts Related to CRK and CRKL.
From: A pre-metazoan origin of the CRK gene family and co-opted signaling network
The diagram illustrates two loci, MONBRDRAFT_25438 and 25437, in the converging orientation (green bars). The yellow bars indicate the coding sequences of the two mRNA transcripts crka1 and crka2 (red bars). The pink bars indicate the predicted SH2 and SH3 domains. The gray bars indicate the exons incorrectly predicted in the provisional models XM_001745882 and XM_001745746. Note that M. brevicollis crka1 mRNA had a splicing pattern different from XM_001745882 at the 5′ end, and that M. brevicollis crka2 mRNA was generated without splicing unlike the predicted model XM_001745746. The pattern of exons and introns in crka1 is supported by the presence of the GT-AG consensus splice site at the boundaries of each intron. Note that M. brevicollis crka2 does not have an intact SH3c domain, since lack of splicing results in a long intervening sequence that divides conserved sequences and also introduces a stop codon (hence, “SH3c?”; see Supplementary Figs S1 and S6 for more information).
