Table 1 ΔI values in SWV for LCP and HP blood plasma samples and LCPP analyzed by LC-18 aptasensor.
From: Electrochemical aptasensor for lung cancer-related protein detection in crude blood plasma samples
Sample group | Sample name | ΔIaptamer-target, μA | ΔIaptamer-IH-SAB 4C–8C, μA | Lung cancer type | Lung cancer stage | MTS | Other diseases | WBS* 109/L | NEU* 109/L | HGB* g/L | Age | Sex |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Lung cancer patients’ blood plasma | 1 | 24.52 | — | Small cell | IV | Brain | Duodenal ulcer, chronic bronchitis | 9.08 | 5.38 | 131 | 59 | M |
2 | 38.73 | — | Squamous | IIA | — | Chronic obstructive pulmonary disease | 8.5 | 5.82 | 119 | 67 | F | |
3 | 42.27 | — | Adenocarcinoma | IIIB | — | Chronic obstructive pulmonary disease, duodenal ulcer | 8.68 | 4.70 | 106 | 65 | M | |
4 | 53.46 | 61.17 | Adenocarcinoma | IIIA | — | Hypertonic disease | 7.04 | 5.21 | 125 | 52 | M | |
5 | 37.23 | 38.83 | Small cell | IIA | — | Cardiac ischemia, myocardial infarction stomach ulcer | 6.32 | 6.11 | 106 | 69 | M | |
6 | 46.40 | 61.91 | Squamous | IIIB | — | Chronic obstructive pulmonary disease | 17.74 | 4.49 | 139 | 66 | M | |
7 | 59.70 | 61.17 | Squamous | IIIB | — | Transient ischemic attack | 12.11 | 5.45 | 112 | 45 | M | |
8 | 25.67 | 28.89 | Adenocarcinoma | IB | — | Paroxysmal atrial fibrillation, gastrectomy for peptic ulcer disease | 10.19 | 6.79 | 146 | 67 | M | |
9 | 46.84 | 52.21 | Squamous and adenocarcinoma (mixed type) | IA | — | Hypertonic disease, duodenal ulcer, chronic bronchitis | 7.87 | 5.02 | 116 | 76 | M | |
Healthy persons’ blood plasma | 10 | 18.37 | — | — | — | — | — | 6.61 | 4.25 | 142 | 62 | M |
11 | 9.85 | — | — | — | — | — | 4.01 | 2.95 | 160 | 30 | M | |
12 | 21.10 | — | — | — | — | — | 7.08 | 5.31 | 125 | 36 | F | |
13 | 18.51 | — | — | — | — | — | 5.15 | 2.37 | 135 | 60 | F | |
Concentration of purified proteins (ng/mL) harvested from blood plasma obtained from patient LC6 | 230 | 21.90 | 24.23 | Squamous | IIIB | — | Chronic obstructive pulmonary disease | 17.74 | 4.49 | 139 | 66 | M |
23 | 12.31 | 19.05 | ||||||||||
2,3 | 7.48 | 18.32 | ||||||||||
0,23 | −1.15 | 8.46 | ||||||||||
0,023 | −3.03 | 4.88 | ||||||||||
0,0023 | −3.44 | 1.3 | ||||||||||
Concentration of purified proteins (ng/mL) harvested from blood plasma obtained from patient LC8 | 230 | 17,4 | 11,01 | Adenocarcinoma | IB | — | Paroxysmal atrial fibrillation, gastrectomy for peptic ulcer disease | 10.19 | 6.79 | 146 | 67 | M |
23 | 13,36 | 12,96 | ||||||||||
2,3 | 1,74 | 11,34 | ||||||||||
0,23 | −5,25 | 2,68 | ||||||||||
0,023 | −4,57 | 1,67 | ||||||||||
0,0023 | −7,76 | −2,4 | ||||||||||
Concentration of purified proteins (ng/mL) harvested from blood plasma obtained from patient LC9 | 230 | 18,4 | 22,57 | Squamous and adenocarcinoma (mixed type) | IA | — | Hypertonic disease, duodenal ulcer, chronic bronchitis | 7.87 | 5.02 | 116 | 76 | M |
23 | 6,55 | 11,89 | ||||||||||
2,3 | 8,25 | 19,15 | ||||||||||
0,23 | 9,19 | 9,8 | ||||||||||
0,023 | 2,53 | 7,6 |
