Table 1 Regression analysis for factors which may influence the geometric mean of the fold increase in antibody titre after first infection.

From: Antibody titres and boosting after natural malaria infection in BK-SE36 vaccine responders during a follow-up study in Uganda

Explanatory variable

N

Fold increase in geometric mean and its ratio

Adjusted GM a [95% CI]

Ratio [95% CI]

Response to BK-SE36 vaccination (based on ≥1.92-fold increase at Day 42)

 Responder

11

3.3 [2.1, 5.3]

2.3 [1.3, 3.8]

1.5 [0.9, 2.6]

 Non responder

26

2.2 [1.6, 3.0]

1.5 [1.0, 2.2]

1.0

 Placebo, Control

40

1.5 [1.2, 1.9]

1.0

 

 p-value

 

0.005

  

Age (yr)

 6–10

30

2.5 [1.9, 3.5]

1.0

 

 11–20

47

1.9 [1.5, 2.5]

0.8 [0.5, 1.13]

 

 p-value

 

0.175

  

Anti-SE36 antibody titre before first infection

 ≤52

44

2.5 [2.0, 3.2]

1.0

 

 >52

33

1.9 [1.4, 2.7]

0.8 [0.5, 1.1]

 

 p-value

 

0.156

  

Parasitemia during the first infection (parasites/μl)

 <5,000

41

1.9 [1.4, 2.5]

1.0

 

 ≥5,000

36

2.6 [2.0, 3.4]

1.4 [0.9, 2.0]

 

 p-value

 

0.091

  
  1. Significant results are shown in bold. N, sample size; GM, geometric mean; CI, confidence interval.
  2. aAll variables shown in the table are adjusted simultaneously using the multivariate linear regression. The p-value refers to the significance of the effect of the regression variable in the model.
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