Table 1 Characteristics of the included studies.
Author | Year | Country | Types of acute intestinal ischemia | Reference standard | Sample size | Male | I-FABP methods of detection | Cut-off value (ng/ml) | Major findings | QUADAS score |
|---|---|---|---|---|---|---|---|---|---|---|
Shi H10 | 2015 | China | Bowel strangulation, mesenteric infarction, ischemic colitis | histopathological examination | 272 | 180 | Enzyme-linked immunosorbent assays | 82.4 | Serum I-FABP and D-lactate can improve the diagnosis of intestinal ischemia in patients with acute abdomen | 12 |
Matsumoto S11 | 2014 | Japan | Non-occlusive ischaemia, mesenteric arterial occlusion | radiological, surgical and histopathological examination | 146 | 98 | Enzyme-linked immunosorbent assays | 9.1 | I-FABP shows promise for detecting vascular ischaemia | 12 |
Kittaka H14 | 2014 | Japan | Strangulated small bowel obstruction | CT findings and operative findings | 37 | 17 | Enzyme-linked immunosorbent assays | 6.5 | The I-FABP level is a useful marker for discriminating strangulated small bowel obstruction from small bowel obstruction | 13 |
Jin H15 | 2014 | China | Mesenteric infarction, focal colonic ischemia | histopathological examination or operative findings | 116 | 73 | Enzyme-linked immunosorbent assays | 101.1 | Serum I-FABP is a useful marker for diagnosis of small bowel ischemia | 9 |
Vermeulen Windsant IC19 | 2012 | Netherlands | Intestinal necrosis after aortic surgery | histopathological examination | 96 | 70 | Synthetic regional peptides and a recombinant I-FABP assays | 5.787 | Analysis of plasma IFABP levels is of additional value to other current plasma markers in the diagnosis of intestinal necrosis | 12 |
Shi H18 | 2012 | China | Mesenteric infarction, ischemic colitis | radiological, surgical and histopathological examination | 151 | 105 | Enzyme-linked immunosorbent assays | 87.52 | I-FABP is a potentially useful for discriminating intestinal ischemia from acute abdomen | 11 |
Kanda T12 | 2011 | Japan | Strangulated bowel obstruction, mesenteric infarction, perforation of the gastrointestinal tract, ischemic enterocolitis | operative findings | 361 | 218 | Enzyme-linked immunosorbent assays | 3.1 | Serum I-FABP measurement is a non-invasive method that is potentially useful for diagnosis of small bowel ischemia | 13 |
Thuijls G13 | 2011 | Netherlands | Acute intestinal ischemia ( did not describe types) | histopathological examination or determined by consensus among 2 of the authors | 46 | 18 | Enzyme-linked immunosorbent assays | 0.268 | Serum I-FABP can improve early diagnosis of intestinal ischemia | 11 |
Cronk DR16 | 2006 | USA | Strangulated small bowel obstruction | operative findings | 21 | NA | Enzyme linked immunosorbent assays | 0.1 | I-FABP is a sensitive marker for ischemia in mechanical small bowel obstruction | 12 |
