Figure 7 | Scientific Reports

Figure 7

From: SDF-1α-induced dual pairs of E-selectin/ligand mediate endothelial progenitor cell homing to critical ischemia

Figure 7

Illustration of a “double-lock” mechanism mediating EPC homing to ischemic wounds tissues for therapeutic neovascularization and wound repair.

SDF-1α acts both locally and remotely to induce ischemic tissue endothelium and BMD-EPC to express E-selectin/ligands. Dual E-selectin/ligand pairs reciprocally expressed on activated endothelium and BMD-EPC mediate enhanced EPC-EC interactions and selective EPC homing.

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