Figure 2

Intra-articular TAK1 overexpression upregulated the expression of OA-related cytokines in rats’ synovial fluid.
Cytokine expression in the synovial fluid from normal, Ad-C and Ad-Tak1 groups was analyzed using biotin label-based rat antibody array (RayBio, AAR-BLG-1). (a) Representative microarray images of each group. (b) The normalized expression changes of OA-related cytokines in synovial fluid of each group based on the microarray result. (c) The network regulation of the aberrantly upregulated cytokines and their contribution to OA pathogenesis.