Table 2 Differentially expressed microRNAs in our study and in other multiple sclerosis studies.

microRNA	Regulation	DE consensus	DE in extra miRNA studies in MS
let-7b-5p	up	16, 17, 18, 19	11,19
let-7g-5p	up	16,18,19	17,46,47
miR-19b-3p	up	16,18,19	19,49,50
miR-20b-5p	down	16, 17, 18	16,17,47,51,52,71
miR-30a-5p	up	16,18,19	16,51, 52, 53
miR-125a-5p	up	16, 17, 18	12,42,72,73
miR-146a-5p	up	16,18,19	19,51,74, 75, 76, 77
miR-186-5p	up	16,18,19	16
miR-221-3p	up	16,18,19	19,47
miR-300	down	16,18,19	—
miR-328	up	16, 17, 18	16,51,53,73
miR-345-5p	up	16, 17, 18, 19	—
miR-363-3p	down	16, 17, 18	46,50,73
miR-379-5p	down	16,18,19	19
miR-450b-5p	down	16,18,19	—
miR-580	down	16,18,19	—
miR-664a-3p	up	16,18,19	—
miR-1206	down	16,18,19	19

Listed under the header “microRNA” are the 18 microRNAs (miRNAs) that were differentially expressed (DE) in our study and that were DE in the same direction in at least three of the four miRNA expression datasets used for this study. A brief description of these miRNA expression datasets can be found in Table 1. “Up” regulated means that a miRNA is expressed at a higher level in multiple sclerosis (MS) patients compared to controls and vice versa for “down” regulation. In the third column, we provide references to the datasets in which we found the miRNAs to be differentially expressed in the same direction in at least three of the four miRNA expression datasets. In the last column, references to additional studies in which these miRNAs are also described as differentially expressed are indicated. miRNA names in bold indicate the 13 miRNAs that were included in the miRNA-based network.

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