Table 4 Differentially expressed microRNAs present in the subnetworks.

Term ID	GO term name	let-7b-5p	let-7g-5p	miR-19b-3p	miR-30a-5p	miR-125a-5p	miR-146a-5p	miR-221-3p	miR-450b-5p	miR-1206
1) Innate immune and inflammatory responses
GO:0002218	Activation of innate immune response					X	X
GO:0002758	Innate immune response-activating signal transduction					X	X
GO:0002224	Toll-like receptor signaling pathway					X	X
GO:0002237	Response to molecule of bacterial origin					X	X
GO:0006954	Inflammatory response		X		X	X	X
2) Immune response and immune system development
GO:0006955	Immune response		X			X	X	X
GO:0002520	Immune system development		X	X	X	X		X		X
3) Immune cells and immune tissue development
GO:0002521	Leukocyte differentiation		X	X	X	X		X
GO:0045321	Leukocyte activation		X	X	X	X	X
GO:0030099	Myeloid cell differentiation		X	X	X	X		X		X
GO:0048534	Hemopoietic or lymphoid organ development		X	X	X	X		X		X
4) Neuron development and plasticity
GO:0030182	Neuron differentiation	X				X	X	X
GO:0050769	Positive regulation of neurogenesis				X	X		X	X
GO:0048666	Neuron development					X	X	X	X
GO:0031175	Neuron projection development					X	X	X	X
GO:0048169	Regulation of long-term neuronal synaptic plasticity	X			X	X		X

Each row corresponds to an enriched immunology- or neurology-related GO term found by performing a functional enrichment analysis using all nodes in the miRNA-based network dysregulated in MS. Four major GO term categories were distinguished. The respective information was used to create subnetworks (Fig. 3a, Supplementary Figs S2–S14). The presence of MS-associated miRNAs in the different subnetworks is marked by “X”.

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