Figure 5
Fluoxetine effectively prevented CUMS-induced increase of depression-like behaviors and cellular senescence in wildtype mice.
(A) CUMS-induced decrease of sucrose consumption in SPT was significantly prevented following fluoxetine treatment for 2 weeks. (B) Fluoxetine treatment effectively prevented CUMS-induced increase of the immobility time and the reduction of the latency to immobility in FST. (C) Fluoxetine treatment effectively prevented CUMS-induced increase of the immobility time in TST. n = 8 mice for each group. (D) Illustration of SABG-staining positive cells within CA1 and DG subareas of CUMS-exposed mice and their controls treated with fluoxetine or vehicle. (E) Fluoxetine treatment effectively prevented the increase of cellular senescence within CA1 and DG subareas of CUMS-exposed mice (n = 6 mice for each group). *P < 0.05; **P < 0.01.
