Figure 3 | Scientific Reports

Figure 3

From: A Novel Resveratrol Based Tubulin Inhibitor Induces Mitotic Arrest and Activates Apoptosis in Cancer Cells

Figure 3

Docking studies showing SS28 interaction with Tubulin in colchicine binding site and the effect of SS28 on microtubule dynamics.

(A) CEM cells were treated with SS28 (2, 5 and 10 μM) and processed for the microtubule assembly assay. Supernatant fractions were resolved in 8% SDS-PAGE. The pellet fractions were immunoblotted using α- Tubulin antibody and quantified. (B) Structure of SS28. (C) Docked pose of SS28 with Tubulin. SS28 can interact with the colchicine binding pocket of Tubulin with the hydrogen bond interaction with Lys 254 and Asn 101. SS28 represented in red and colchicine in blue colour.

Back to article page