Figure 7
Impact of SS28 on tumor bearing mouse and evaluation of side effects of SS28 in normal BALB/c mice.
(A) Nine doses of SS28 (15 mg/kg. b.wt.) were administered orally on every alternate day from 12th day of EAC cell injection in mice. Data shows volume of tumor measured at different time intervals, with and without treatment of SS28. Results depicted from three independent batches of experiments containing 10 animals each. (B) Mice were orally administered with nine doses of SS28 (15 mg/kg) on every alternate day. Data represented as average body weight in both the controls and SS28 treated mice. Error bars indicate SEM. (C–E) Hematological profile and renal and liver functional assay. Blood was collected on the 21st day of the treatment counted RBC and WBC (C) and serum was tested for alkaline phosphatase (ALP), alanine aminotransferase (ALT) (D), urea and creatinine (E). Columns represent mean from five animals in each group; bars SEM. (F) Pharmacokinetics of SS28 in mice plasma. SS28 was injected intraperitonealy to mice and blood was collected and processed as described in materials and methods. Data represented in time points versus the peak area as the function of the concentration of SS28 in plasma.
