Figure 1

Tollip^−/− mice are more susceptible to DSS induced acute colon injury.

(A) Schematic of the acute model of DSS-induced ulcerative colitis. (B) Weight loss of WT, Tollip^−/− naïve mice and DSS-treated WT, Tollip^−/− mice. (C) The survive curve. (D) Length and gross morphology of colon. (E) Average clinical scores (weight loss, stool consistency, bleeding) of indicated mice. (F) Representative H&E staining in colon tissues from WT and Tollip^−/− mice at day 0, day 6, day 12 after subjected to DSS, and, histology assessment according to criteria in Supplementary Fig. 2. (DSS-treated WT, n = 25; DSS-treated Tollip^−/−, n = 26). The symbol *,***indicated P < 0.05, P < 0.001 between the DSS-treated gene-deficient strains compared with DSS-treated WT. The symbols ^##,^###indicated P < 0.01, P < 0.001 and ^&&&P < 0.001, between the WT control and DSS-treated WT or between Tollip^−/− control and DSS-treated Tollip^−/− mice, respectively. WT control, n = 7; Tollip^−/− control, n = 7; DSS-treated WT, n = 22; DSS-treated Tollip^−/−, n = 15. Error bars have been omitted from the weight loss data and clinical score data for clarity of presentation.