Table 2 Quantification of SPLs (VIP > 1) in A2780 and A2780T.

From: LC-MS Based Sphingolipidomic Study on A2780 Human Ovarian Cancer Cell Line and its Taxol-resistant Strain

SPLs

Content (pmol/5*105 cells)

Change A2780T vs A2780

p value

VIP

A2780 (n = 10)

A2780T (n = 10)

SM(d18:2/23:0)

1.91 ± 0.06

1.15 ± 0.03

↓

<0.001

1.09801

SM(d18:2/22:0)

5.68 ± 0.16

3.19 ± 0.09

↓

<0.001

1.13525

SM(d18:2/20:0)

1.14 ± 0.03

0.30 ± 0.02

↓

<0.001

1.16777

SM(d18:1/26:1)

1.23 ± 0.04

0.57 ± 0.02

↓

<0.001

1.13507

SM(d18:1/26:0)

0.39 ± 0.01

0.85 ± 0.02

↑

<0.001

1.15741

SM(d18:1/25:1)

1.09 ± 0.03

0.81 ± 0.02

↓

<0.001

1.01815

SM(d18:1/25:0)

0.69 ± 01

1.16 ± 0.02

↑

<0.001

1.11518

SM(d18:1/24:3)

0.85 ± 0.04

0.21 ± 0.01

↓

<0.001

1.14943

SM(d18:1/24:2)

22.5 ± 0.42

4.00 ± 0.09

↓

<0.001

1.18383

SM(d18:1/24:1)

94.6 ± 1.80

22.5 ± 0.65

↓

<0.001

1.18238

SM(d18:1/24:0)

35.6 ± 0.64

55.1 ± 1.33

↑

<0.001

1.13437

SM(d18:1/23:2)

0.72 ± 0.02

0.04 ± 0.00

↓

<0.001

1.15961

SM(d18:1/23:1)

8.43 ± 0.18

1.27 ± 0.04

↓

<0.001

1.18228

SM(d18:1/22:2)

0.49 ± 0.03

0.08 ± 0.01

↓

<0.001

1.13820

SM(d18:1/22:1)

8.00 ± 0.16

0.84 ± 0.03

↓

<0.001

1.18362

SM(d18:1/21:1)

0.32 ± 0.01

0.05 ± 0.00

↓

<0.001

1.14304

SM(d18:1/21:0)

1.60 ± 0.04

0.62 ± 0.02

↓

<0.001

1.16306

SM(d18:1/20:0)

3.89 ± 0.09

2.02 ± 0.07

↓

<0.001

1.15126

SM(d18:1/19:0)

0.54 ± 0.03

0.15 ± 0.01

↓

<0.001

1.11029

SM(d18:1/18:1)

31.7 ± 0.03

5.77 ± 0.01

↓

<0.001

1.18432

SM(d18:1/18:0)

28.7 ± 0.48

7.54 ± 0.31

↓

<0.001

1.18301

SM(d18:1/17:0)

4.63 ± 0.12

7.27 ± 0.20

↑

<0.001

1.11640

SM(d18:1/16:1)

27.3 ± 0.47

40.1 ± 0.91

↑

<0.001

1.12871

SM(d18:1/16:0)

431 ± 20.9

606 ± 40.4

↑

<0.001

1.11932

SM(d18:1/15:0)

20.0 ± 0.32

14.1 ± 0.26

↓

<0.001

1.14185

SM(d18:1/14:0)

20.9 ± 0.28

15.6 ± 0.27

↓

<0.001

1.13645

DHSM(d18:0/24:0)

0.54 ± 0.01

4.96 ± 0.13

↑

<0.001

1.18082

DHSM(d18:0/23:0)

0.11 ± 0.00

0.81 ± 0.02

↑

<0.001

1.17627

DHSM(d18:0/22:0)

0.74 ± 0.02

3.35 ± 0.08

↑

<0.001

1.17865

DHSM(d18:0/20:0)

0.27 ± 0.01

0.49 ± 0.02

↑

<0.001

1.04670

DHSM(d18:0/18:0)

1.06 ± 0.03

1.87 ± 0.06

↑

<0.001

1.12766

DHSM(d18:0/16:0)

30.1 ± 0.70

198 ± 5.28

↑

<0.001

1.17911

DHSM(d18:0/14:0)

0.72 ± 0.02

2.59 ± 0.08

↑

<0.001

1.17037

DHSM(t18:0/16:0)

0.11 ± 0.01

0.27 ± 0.03

↑

<0.001

1.07421

Cer(d18:2/22:0)

1.07 ± 0.08

0.23 ± 0.04

↓

<0.001

1.09314

Cer(d18:1/24:2)

0.24 ± 0.03

0.02 ± 0.00

↓

<0.001

1.02636

Cer(d18:1/24:1)

14.6 ± 0.59

1.60 ± 0.07

↓

<0.001

1.17972

Cer(d18:1/24:0)

14.6 ± 0.27

5.97 ± 0.20

↓

<0.001

1.17416

Cer(d18:1/23:1)

0.26 ± 0.03

0.02 ± 0.00

↓

<0.001

1.02345

Cer(d18:1/23:0)

1.02 ± 0.04

0.42 ± 0.03

↓

<0.001

1.12215

Cer(d18:1/23:0(OH))

0.48 ± 0.03

0.22 ± 0.02

↓

<0.001

1.02341

Cer(d18:1/22:0)

2.23 ± 0.10

1.16 ± 0.08

↓

<0.001

1.06470

Cer(d18:1/18:1)

6.39 ± 0.23

4.09 ± 0.25

↓

<0.001

1.01738

Cer(d18:1/18:0)

1.62 ± 0.13

0.20 ± 0.04

↓

<0.001

1.10112

Cer(d17:1/16:0)

2.24 ± 0.12

0.47 ± 0.06

↓

<0.001

1.13502

HexCer(d18:1/24:0)

11.7 ± 0.40

2.70 ± 0.18

↓

<0.001

1.16555

HexCer(d18:1/23:0)

1.14 ± 0.40

0.21 ± 0.18

↓

<0.001

1.04684

HexCer(d18:1/22:0)

2.89 ± 0.11

0.85 ± 0.11

↓

<0.001

1.12835

HexCer(d18:1/16:0)

19.3 ± 0.67

6.11 ± 0.49

↓

<0.001

1.15137

LacCer(d18:1/24:1)

5.48 ± 0.43

0.08 ± 0.01

↓

<0.001

1.12942

LacCer(d18:1/24:0)

4.49 ± 0.36

0.84 ± 0.12

↓

<0.001

1.09150

LacCer(d18:1/16:0)

7.59 ± 0.45

1.93 ± 0.17

↓

<0.001

1.11980

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