Figure 2
From: Upregulation of ANGPTL6 in mouse keratinocytes enhances susceptibility to psoriasis
S100a8 and S100a9 levels increase in psoriasis-like lesions of K14-Angptl6 Tg mice.
(a) The top 30-upregulated mRNAs in psoriatic-like lesions from 20 weeks of age of K14-Angptl6 Tg relative to wild-type littermate mice. Genes shown in red were previously reported to be psoriatic-related genes11,23,24,25,26,27,28. (b) S100a8 and S100a9 transcript levels in psoriatic-like lesions of wild-type or K14-Angptl6 Tg mice at 20 weeks of age. Values for respective WT mice were set to 1 (n = 4–5 per each group). Data are means ± SEM. *p < 0.05, **p < 0.01 between genotypes. (c) Immunohistochemistry staining for S100a8 and S100a9 in neck skin of WT and K14-Angptl6 Tg mice at 20 weeks of age. Scale bar: 100 μm.
