Figure 2 | Scientific Reports

Figure 2

From: Scaffold Hopping Toward Agomelatine: Novel 3, 4-Dihydroisoquinoline Compounds as Potential Antidepressant Agents

Figure 2

General synthetic route of 3, 4-dihydroisoquinoline compounds 6a and 6b.

Reagents and conditions: (i) β-alanine, AcOH, reflux, 4 h; (ii) 2-(4-methoxyphenyl)ethan–1-amine hydrochloride, EDCI, Pyridine, r.t., 24 h; (iii) P2O5, POCl3, 130 °C, 4 h; (iv) HCl(aq.), reflux, 8 h; (v) Acyl chloride or anhydride/EDCI, r. t., 10 h; carboxylic acid/EDCI/pyridine, r.t., 10 h; (vi) amine, CDI, 0 °C-r.t., 10 h; (vii) sulfonyl chloride, EDCI, r.t., 10 h.

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