Table 1 The protection rates of the target compounds on corticosterone-injured PC12 cells.

From: Scaffold Hopping Toward Agomelatine: Novel 3, 4-Dihydroisoquinoline Compounds as Potential Antidepressant Agents

Compd.

PRa (%)

1.25 μM

2.5 μM

5 μM

6a-1

25.4

37.1

42.1

6a-2

32.7

18.1

3.1

6a-9

20.3

14.9

7.9

Ago.

28.1

24.2

17.6

  1. aPR represents the protection rate of the tested compounds measured at 24 h after treatment with different concentrations of compounds. PR = (Ad − Ac)/Ac * 100%.
Back to article page