Figure 5
Putative dsDNA and CDN binding sites of DDX41.
(A) Docking model of the DDX41 DEAD domain bound to dsDNA. The dsDNA is colored brown. (B) Electrostatic surface potentials of the DDX41 closed form (contoured from −10 kT e−1 [red] to +10 kT e−1 [blue]). (C) Pull-down assays of the DEAD mutants and bio-ISD. (D) Pull-down assays of the DEAD mutants and bio-cGG. Gels were run under the same experimental conditions and are shown as cropped gels. Full-length gels with the cropping lines indicated are shown in Figure S7.
