Figure 6
The dsDNA/CDN-binding surface of DDX41 is critical for the innate-immune responses.
(A,B) Quantitative PCR analyses of IFNB1 (A) and IFIT2 (B) transcription in THP-1 cells. The cells were treated with shRNA targeting the mRNA encoding DDX41, and then transfected with vectors expressing FL-DDX41 WT or mutants. Gels were run under the same experimental conditions and are shown as cropped blots. Full-length blots with the cropping lines indicated are shown in Figure S7.
