Figure 2
Lobular pancreatic β-cell volumes in ob/ob and lean controls.
(A) Graph illustrating the total average (black lines) and lobular splenic (SL, red), duodenal (DL, green) and gastric (GL, yellow) β-cell volumes in lean control (broken lines) and ob/ob pancreata (intact lines). The BCV expansion is close to linear in all groups (r2 scores are indicated). (B) Graph displaying the average percentual β-cell volume in the respective splenic, duodenal and gastric lobes of lean control (white bars) and ob/ob (black bars). Inset shows a photomicrograph of a gut segment including the stomach, duodenum, spleen and pancreas from a C57Bl/6 mouse at 8 weeks, illustrating the delineation of the lobes. Data is shown as means ± SEM (n = 5) where *P < 0.05; **P < 0.01 and ***P < 0.001. Abbreviations: SL, Splenic lobe; DL, Duodenal lobe; GL, Gastric lobe; St, Stomach; Spl, Spleen; Duo, Duodenum. Scale bar in inset is 2 mm.
