Table 4 Interactions between SNPs in genes in acrylamide metabolism and dietary acrylamide intake on the risk of endometrial cancer, 11.3 years of follow-up.

From: The influence of single nucleotide polymorphisms on the association between dietary acrylamide intake and endometrial cancer risk

Gene, SNP*

Acrylamide, continuous intake

Acrylamide, tertiles of intake

P for interaction

Tertile 1

Tertile 2

Tertile 3

P for trend

10 μg/day

N cases

HR (95% CI)

N cases

HR (95% CI)

N cases

HR (95% CI)

Raw p

Benjamini-Hochberg p value

All women

ā€ƒCYP2E1, rs915906 = 0

1.17 (1.01–1.35)

31

Ref (1.00)

38

1.28 (0.74–2.20)

58

1.90 (1.15–3.12)

0.01

0.02

0.83

ā€ƒCYP2E1, rs915906 = 1

0.75 (0.50–1.12)

21

Ref (1.00)

18

1.07 (0.49–2.34)

12

0.73 (0.30–1.76)

0.49

Ā Ā 

Never-smokers

ā€ƒCYP2E1, rs915906 = 0

1.34 (1.09–1.63)

21

Ref (1.00)

25

1.40 (0.71–2.75)

41

2.31 (1.26–4.21)

0.006

0.07

0.61

ā€ƒCYP2E1, rs915906 = 1

0.91 (0.55–1.49)

11

Ref (1.00)

13

1.70 (0.65–4.43)

9

1.21 (0.41–3.56)

0.74

Ā Ā 

All women

ā€ƒCYP2E1, rs2480258 = 0

1.22 (1.02–1.45)

28

Ref (1.00)

31

1.31 (0.72–2.37)

46

1.82 (1.06–3.11)

0.03

0.03

0.83

ā€ƒCYP2E1, rs2480258 = 1

0.88 (0.69–1.11)

24

Ref (1.00)

25

1.09 (0.56–2.12)

24

1.13 (0.57–2.23)

0.74

Ā Ā 

Never-smokers

ā€ƒCYP2E1, rs2480258 = 0

1.37 (1.10–1.72)

20

Ref (1.00)

21

1.44 (0.70–2.96)

34

2.24 (1.19–4.20)

0.01

0.11

0.70

ā€ƒCYP2E1, rs2480258 = 1

0.96 (0.71–1.31)

12

Ref (1.00)

17

1.70 (0.76–3.83)

16

1.56 (0.65–3.74)

0.34

Ā Ā 

All women

ā€ƒGSTM1 1 or 2 copies, all SNPs

1.12 (0.97–1.30)

36

Ref (1.00)

36

1.04 (0.60–1.81)

59

1.66 (1.00–2.74)

0.04

0.14†

0.92

ā€ƒGSTM1 deleted, all SNPs

0.90 (0.63–1.30)

16

Ref (1.00)

20

1.68 (0.71–3.99)

11

0.93 (0.39–2.21)

0.94

Ā Ā 

Never-smokers

ā€ƒGSTM1 1 or 2 copies, all SNPs

1.25 (1.05–1.49)

21

Ref (1.00)

24

1.52 (0.75–3.05)

42

2.56 (1.39–4.68)

0.002

0.28

0.86

ā€ƒGSTM1 deleted, all SNPs

0.90 (0.53–1.54)

11

Ref (1.00)

14

1.78 (0.67–4.72)

8

0.78 (0.27–2.23)

0.73

Ā Ā 

All women

ā€ƒGSTT1 1 or 2 copies, all SNPs

1.13 (0.98–1.30)

48

Ref (1.00)

52

1.23 (0.78–1.93)

66

1.60 (1.04–2.44)

0.03

0.07

0.92

ā€ƒGSTT1 deleted, all SNPs

0.55 (0.23–1.28)

4

Ref (1.00)

4

0.83 (0.13–5.41)

4

0.28 (0.03–2.77)

0.24

Ā Ā 

Never-smokers

ā€ƒGSTT1 1 or 2 copies, all SNPs

1.33 (1.10–1.61)

29

Ref (1.00)

35

1.56 (0.88–2.76)

49

2.35 (1.39–3.98)

0.001

0.02

0.61

ā€ƒGSTT1 deleted, all SNPs

0.43 (0.19–0.97)

3

Ref (1.00)

3

0.83 (0.17–4.10)

1

0.13 (0.01–2.05)

0.08

Ā Ā 
  1. Adjusted for age (yrs), age at menarche (yrs), age at menopause (yrs), parity (n children), ever use of oral contraceptives (yes/no), ever use of postmenopausal hormone use (yes/no), BMI (kg/m2), current smoking (yes/no), quantity of smoking (cigarettes/day), duration of smoking (n smoking years), family history of endometrial cancer (yes/no),energy intake (kcal/day).
  2. *0 = homozygous wild type, 1 = 1 or 2 variant alleles.
  3. †p for interaction borderline statistically significant (p = 0.09) when deletion was based on missing calls for rs200184852.