Table 4 Interactions between SNPs in genes in acrylamide metabolism and dietary acrylamide intake on the risk of endometrial cancer, 11.3 years of follow-up.
Gene, SNP* | Acrylamide, continuous intake | Acrylamide, tertiles of intake | P for interaction | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Tertile 1 | Tertile 2 | Tertile 3 | P for trend | |||||||
10 μg/day | N cases | HR (95% CI) | N cases | HR (95% CI) | N cases | HR (95% CI) | Raw p | Benjamini-Hochberg p value | ||
All women | ||||||||||
āCYP2E1, rs915906ā=ā0 | 1.17 (1.01ā1.35) | 31 | Ref (1.00) | 38 | 1.28 (0.74ā2.20) | 58 | 1.90 (1.15ā3.12) | 0.01 | 0.02 | 0.83 |
āCYP2E1, rs915906ā=ā1 | 0.75 (0.50ā1.12) | 21 | Ref (1.00) | 18 | 1.07 (0.49ā2.34) | 12 | 0.73 (0.30ā1.76) | 0.49 | Ā | Ā |
Never-smokers | ||||||||||
āCYP2E1, rs915906ā=ā0 | 1.34 (1.09ā1.63) | 21 | Ref (1.00) | 25 | 1.40 (0.71ā2.75) | 41 | 2.31 (1.26ā4.21) | 0.006 | 0.07 | 0.61 |
āCYP2E1, rs915906ā=ā1 | 0.91 (0.55ā1.49) | 11 | Ref (1.00) | 13 | 1.70 (0.65ā4.43) | 9 | 1.21 (0.41ā3.56) | 0.74 | Ā | Ā |
All women | ||||||||||
āCYP2E1, rs2480258ā=ā0 | 1.22 (1.02ā1.45) | 28 | Ref (1.00) | 31 | 1.31 (0.72ā2.37) | 46 | 1.82 (1.06ā3.11) | 0.03 | 0.03 | 0.83 |
āCYP2E1, rs2480258ā=ā1 | 0.88 (0.69ā1.11) | 24 | Ref (1.00) | 25 | 1.09 (0.56ā2.12) | 24 | 1.13 (0.57ā2.23) | 0.74 | Ā | Ā |
Never-smokers | ||||||||||
āCYP2E1, rs2480258ā=ā0 | 1.37 (1.10ā1.72) | 20 | Ref (1.00) | 21 | 1.44 (0.70ā2.96) | 34 | 2.24 (1.19ā4.20) | 0.01 | 0.11 | 0.70 |
āCYP2E1, rs2480258ā=ā1 | 0.96 (0.71ā1.31) | 12 | Ref (1.00) | 17 | 1.70 (0.76ā3.83) | 16 | 1.56 (0.65ā3.74) | 0.34 | Ā | Ā |
All women | ||||||||||
āGSTM1 1 or 2 copies, all SNPs | 1.12 (0.97ā1.30) | 36 | Ref (1.00) | 36 | 1.04 (0.60ā1.81) | 59 | 1.66 (1.00ā2.74) | 0.04 | 0.14ā | 0.92 |
āGSTM1 deleted, all SNPs | 0.90 (0.63ā1.30) | 16 | Ref (1.00) | 20 | 1.68 (0.71ā3.99) | 11 | 0.93 (0.39ā2.21) | 0.94 | Ā | Ā |
Never-smokers | ||||||||||
āGSTM1 1 or 2 copies, all SNPs | 1.25 (1.05ā1.49) | 21 | Ref (1.00) | 24 | 1.52 (0.75ā3.05) | 42 | 2.56 (1.39ā4.68) | 0.002 | 0.28 | 0.86 |
āGSTM1 deleted, all SNPs | 0.90 (0.53ā1.54) | 11 | Ref (1.00) | 14 | 1.78 (0.67ā4.72) | 8 | 0.78 (0.27ā2.23) | 0.73 | Ā | Ā |
All women | ||||||||||
āGSTT1 1 or 2 copies, all SNPs | 1.13 (0.98ā1.30) | 48 | Ref (1.00) | 52 | 1.23 (0.78ā1.93) | 66 | 1.60 (1.04ā2.44) | 0.03 | 0.07 | 0.92 |
āGSTT1 deleted, all SNPs | 0.55 (0.23ā1.28) | 4 | Ref (1.00) | 4 | 0.83 (0.13ā5.41) | 4 | 0.28 (0.03ā2.77) | 0.24 | Ā | Ā |
Never-smokers | ||||||||||
āGSTT1 1 or 2 copies, all SNPs | 1.33 (1.10ā1.61) | 29 | Ref (1.00) | 35 | 1.56 (0.88ā2.76) | 49 | 2.35 (1.39ā3.98) | 0.001 | 0.02 | 0.61 |
āGSTT1 deleted, all SNPs | 0.43 (0.19ā0.97) | 3 | Ref (1.00) | 3 | 0.83 (0.17ā4.10) | 1 | 0.13 (0.01ā2.05) | 0.08 | Ā | Ā |