Figure 6 | Scientific Reports

Figure 6

From: cAMP-PKA-CaMKII signaling pathway is involved in aggravated cardiotoxicity during Fuzi and Beimu Combination Treatment of Experimental Pulmonary Hypertension

Figure 6

Active components of Beimu inhibit PDK1/Akt/PDE axis, down-regulating the phosphorylation of Akt and PDE.

Western blot analysis of p-PDK1, PDK1, p-Akt, Akt, and PDE4D levels in H9C2 cells (A) n = 3. Synergistic effect of Beimu with Fuzi on increasing cAMP levels (B). The influence of Combination on activating β2AR in β2 HEK 293 cells by a Luciferase reporter gene assay (n = 6). *P < 0.0,5, **P < 0.01 vs control.

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