Figure 3
From: Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons
Calcium dysregulation and neuronal loss of FTLD-Tau neurons.
(a,b) Calcium imaging after electrical stimulation. Intracellular Ca2+ levels, elevated by electrical stimulation, were higher in FTLD-Tau neurons than in control (n = 6; one-way ANOVA, p < 0.05; post hoc test, *p < 0.05). (c,d) Immunofluorescence staining of βIII tubulin and NeuN on Days 8 and 21 in control and FTLD-Tau neurons. Survival of FTLD-Tau neurons from Day 8 to Day 21 was decreased compared to control neurons (n = 6; one-way ANOVA, p < 0.05; post hoc test, *p < 0.05).
