Figure 3
Comparison of the expression of serum and hepatic miRNAs in patients with chronic hepatitis B and C.
The expression of serum (A–I) and hepatic (J–R) expression of miR-20a, miR-21, miR-29a, miR-92a, miR-122, miR-146a, miR-221, miR-222 and miR-224 was assessed by RT-qPCR and compared in patients with CHC and CHB. (A–I) In serum samples, The ΔCt (ΔCt = 2ΔCp,sample) of each miRNA was calculated and normalized to the ΔCt value of the exogenous C. elegans-miR-39 (cel-miR-39) in each serum. The log expression of the ratio miRNA/cel-miR-39 is shown as dot plot, each dot represents one patient (mean and standard deviation). (J–R) In liver samples, the ΔCt (ΔCt = 2ΔCp,sample) of each miRNA was calculated and normalized to the ΔCt value of SNORD44 in each biopsy. The log expression of the ratio miRNA/SNORD44 is shown as dot plot, each dot represents one patient (mean and standard deviation). The log expression of the ratio miRNA/SNORD44 is shown as dot plot, each dot represents one patient (mean and standard deviation). The Wilcoxon rank-sum test was used to compare miRNAs expression.
