Figure 1

Effect of MC4R and MC3R deficiency on body weight, body length and Lee’s index.

(a) Body weight and (b) Relative body weight were measured from postnatal day (PND) 45 to 85 for Mc3r KO, Mc4r KO, DKO and WT littermates (n = 8 except 6 for DKO, repeated measures analysis followed by Bonferroni post-tests). Nose-anus length (c,d) and Lee’s index (e,f) of Mc3r KO, Mc4r KO, and DKO rats vs. WT littermates (n = 8 except 4 for DKO) at 14 weeks of age (one-way ANOVA test). Data are shown as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 vs. WT control.