Figure 5
Validating ovarian cancer markers captured in MS-based proteomics screening on arrays of histotype-specific tumour materials.
A TMA containing 485 ovarian cancers was stained for CTH. Shown are the data for the HGSC, CCC and ENOC histotypes. (a) Violin plot depicting the densities of individuals scored based on expression of the marker CTH. Histotypes are listed along the x-axis. Proportions of positively staining tumours is displayed as a percentage at the matched score level. Sections on the TMA were scored manually based on a system of 0 = negative, 1 = weak or variable, 2 = strong straining. P-values were calculated using a Mann-Whitney U-test. (b) Representative images showing the staining for each of the histotypes are shown.
