Figure 4 | Scientific Reports

Figure 4

From: AML1/ETO accelerates cell migration and impairs cell-to-cell adhesion and homing of hematopoietic stem/progenitor cells

Figure 4

EMT regulators are altered in EML cells expressing AML1/ETO.

(A) GSEA plot of EMT-related signatures in EML-EML-AE22 versus EML-EV control cells. FDR: False Discovery Rate; NES: Normalized Enrichment Score. (B,C) BloodSpot plots showing the expression data taken from different public EMT signatures in AML subtypes and healthy HSC/MPP cells. For each sample, the expression values in single datasets included in the analysis and the median value for each cohort are shown. (D,E) Cdh1 (D) and Zeb2 (E) expression levels were measured by RT-qPCR in Lin- with or without expression of AML1/ETO and in EML-EV and EML-AE22 cells. Levels are relative to Tbp expression and normalized for expression in the control cells.

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