Table 2 Association between HLA DQB1 and DRB1 alleles with GDM.

HLA	Number of populations	OR (95%CI)	P	Adjusted P	P _h	I²
DQB1*02	6	1.36 (1.13–1.63)	0.001	0.034	0.538	0
DQB1*0201	6	1.48 (0.89–2.47)	0.129	1	0.044	56.23
DQB1*0203	2	3.27 (1.21–8.81)	0.019	0.646	0.601	0
DQB1*0301	4	0.90 (0.55–1.47)	0.673	1	0.017	70.40
DQB1*0302	9	1.03 (0.88–1.20)	0.755	1	0.780	0
DQB1*0303	3	1.05 (0.57–1.95)	0.866	1	0.792	0
DQB1*0305	3	0.93 (0.41–2.12)	0.857	1	0.611	0
DQB1*0401	2	0.82 (0.31–2.18)	0.694	1	0.984	0
DQB1*0402	4	0.35 (0.16–0.78)	0.010	0.340	0.718	0
DQB1*0501	3	1.03 (0.63–1.71)	0.899	1	0.948	0
DQB1*0502	4	1.12 (0.57–2.19)	0.744	1	0.597	0
DQB1*0503	3	0.73 (0.29–1.82)	0.497	1	0.540	0
DQB1*0601	4	0.62 (0.29–1.30)	0.205	1	0.113	49.81
DQB1*0602	11	0.74 (0.64–0.86)	0.0001	0.0034	0.187	27.00
DQB1*0603	4	0.86 (0.68–1.08)	0.194	1	0.848	0
DQB1*0604	3	1.27 (0.59–2.74)	0.545	1	0.428	0
DRB1*01	4	0.73 (0.52–1.03)	0.075	1	0.468	0
DRB1*02	2	1.30 (0.96–1.75)	0.087	1	0.314	1.49
DRB1*03	4	1.37 (1.03–1.83)	0.031	1	0.482	0
DRB1*0301	5	3.16 (1.31–7.64)	0.011	0.374	0.012	68.84
DRB1*04	4	1.42 (0.97–2.08)	0.071	1	0.118	48.95
DRB1*0402	2	0.59 (0.21–1.67)	0.319	1	0.452	0.00
DRB1*0405	2	1.01 (0.12–8.40)	0.994	1	0.149	51.87
DRB1*07	4	1.28 (0.94–1.74)	0.117	1	0.563	0
DRB1*08	4	0.91 (0.47–1.77)	0.781	1	0.750	0
DRB1*09	4	1.11 (0.72–1.70)	0.642	1	0.414	0
DRB1*10	3	0.96 (0.29–3.22)	0.949	1	0.301	16.82
DRB1*11	3	0.81 (0.51–1.28)	0.365	1	0.805	0
DRB1*12	3	0.80 (0.51–1.26)	0.342	1	0.513	0
DRB1*13	2	0.84 (0.18–3.88)	0.819	1	0.298	7.75
DRB1*1302	3	3.37 (2.03–5.60)	2.7 × 10⁻⁶	9.2 × 10⁻⁵	0.666	0
DRB1*14	2	0.89 (0.43–1.83)	0.750	1	0.896	0
DRB1*15	2	0.60 (0.25–1.48)	0.270	1	0.138	54.48
DRB1*16	2	1.58 (0.63–3.92)	0.328	1	0.279	14.82

OR odds ratio, CI confidence interval, P probability tested for overall effect, Adjusted P corrected p-values after Bonferroni correction, P_h probability tested for heterogeneity of included studies.

Search