Table 3 Association between HLA-DQ and -DR antigens with GDM.

From: The relationships between HLA class II alleles and antigens with gestational diabetes mellitus: A meta-analysis

HLA

Number of populations

OR (95% CI)

P

Adjusted P

P h

I 2

DQ2

12

1.36 (1.10–1.67)

0.004

0.088

0.058

42.60

DQ4

4

0.50 (0.23–1.09)

0.082

1

0.982

0

DQ5

4

0.98 (0.70–1.37)

0.895

1

0.760

0

DQ6

11

0.81 (0.69–0.94)

0.008

0.176

0.743

0

DQ7

4

0.90 (0.55–1.47)

0.674

1

0.018

70.40

DQ8

10

1.02 (0.87–1.19)

0.802

1

0.840

0

DQ9

3

1.05 (0.57–1.96)

0.865

1

0.792

0

DR1

4

1.50 (0.99–2.27)

0.056

1

0.493

0

DR2

3

0.83 (0.57–1.22)

0.346

1

0.250

27.92

DR3

4

0.88 (0.41–1.88)

0.733

1

0.101

51.83

DR4

4

1.13 (0.81–1.56)

0.468

1

0.149

43.78

DR5

2

0.68 (0.34–1.38)

0.290

1

0.111

60.57

DR6

2

2.46 (0.87–6.92)

0.089

1

0.380

0

DR7

7

1.23 (0.97–1.56)

0.082

1

0.475

0

DR8

4

0.92 (0.49–1.72)

0.791

1

0.817

0

DR9

6

1.19 (0.80–1.78)

0.387

1

0.520

0

DR10

4

0.78 (0.25–2.39)

0.658

1

0.347

9.17

DR12

4

0.81 (0.52–1.26)

0.354

1

0.711

0

DR13

4

2.46 (1.02–5.90)

0.044

0.968

0.028

66.94

DR15

2

0.59 (0.27–1.31)

0.196

1

0.325

0

DR16

3

1.45 (0.64–3.33)

0.375

1

0.510

0

DR17

5

3.16 (1.31–7.64)

0.011

0.242

0.012

68.84

  1. OR odds ratio, CI confidence interval, P probability tested for overall effect, Adjusted P corrected p-values after Bonferroni correction, Ph probability tested for heterogeneity of included studies.
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