Table 3 Performance of PIVKA-II and AFP in differentiating HCC cases from controls at different cut-off values at diagnostic time.
Cut-off values | Sensitivity | Specificity | Youden Index | Diagnostic accuracy | Positive predictive value | Negative predictive value | Kappa index | χ2 |
|---|---|---|---|---|---|---|---|---|
PIVKA-II (mAU/ml) | ||||||||
32 | 54.9% | 92.8% | 47.7% | 83.3% | 71.8% | 84.7% | 0.520 | 40.0 |
40 | 45.1% | 97.8% | 42.9% | 83.6% | 88.5% | 82.8% | 0.508 | 57.8 |
80 | 37.3% | 99.3% | 36.6% | 82.5% | 95.0% | 81.1% | 0.452 | 52.5 |
400 | 23.5% | 100% | 23.5% | 79.4% | 100% | 78.0% | 0.310 | 34.7 |
AFP (ng/ml) | ||||||||
5 | 74.5% | 87.0% | 61.5% | 84.0% | 67.9% | 90.2% | 0.593 | 51.0 |
20 | 43.1% | 98.6% | 41.7% | 83.6% | 91.7% | 82.4% | 0.500 | 58.4 |
40 | 35.3% | 99.3% | 34.6% | 82.0% | 94.7% | 80.6% | 0.431 | 49.2 |
200 | 19.6% | 100% | 19.6% | 78.3% | 100% | 77.1% | 0.263 | 28.6 |
