Table 2 Incidence of Pregnancy and Perinatal Complications in ART and Spontaneously Pregnant Groups with Stratified Analysis by Birth Plurality.
Total | Singletons | Twins | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
ART (n = 2641) | Controls (n = 5282) | P | Adjusted OR (95% CI) | ART (n = 1659) | Controls (n = 5193) | P | Adjusted OR (95% CI) | ART (n = 982) | Controls (n = 89) | P | Adjusted OR (95% CI) | |
Pregnancy complications | ||||||||||||
GDM | 309 (11.7) | 342 (6.5) | <0.001 | 1.99 (1.69–2.36) | 214 (12.9) | 334 (6.4) | <0.001 | 2.23 (1.85–2.69) | 95 (9.7) | 8 (9.0) | 1 | — |
Gestational hypertension | 249 (9.4) | 189 (3.6) | <0.001 | 2.58 (2.11–3.15) | 124 (7.5) | 183 (3.5) | <0.001 | 1.99 (1.56–2.53) | 125 (12.7) | 6 (6.7) | 0.127 | — |
Preeclampsia | 98 (3.7) | 110 (2.1) | <0.001 | 1.49 (1.12–1.98) | 43 (2.6) | 107 (2.1) | 0.21 | 1.71 (1.34–2.19) | 55 (5.6) | 3 (3.4) | 0.471 | — |
mild preeclampsia | 35 (1.3) | 56 (1.1) | 0.315 | — | 15 (0.9) | 55 (1.1) | 0.675 | 0.60 (0.33–1.09) | 20 (2.0) | 1 (1.1) | 1 | — |
severe preeclampsia | 63 (2.5) | 54 (1.0) | <0.001 | 2.04 (1.40–2.96) | 28 (1.7) | 52 (1.0) | 0.035 | 1.52 (0.95–2.43) | 35 (3.6) | 2 (2.3) | 0.763 | — |
ICP | 302 (11.4) | 228 (4.3) | <0.001 | 2.86 (2.39–3.42) | 110 (6.6) | 214 (4.1) | <0.001 | 1.59 (1.25–2.02) | 192 (19.6) | 14 (15.7) | 0.482 | — |
Perinatal complications | ||||||||||||
Placenta previa | 185 (7.0) | 179 (3.4) | <0.001 | 2.23 (1.79–2.78) | 117 (7.1) | 175 (3.4) | <0.001 | 2.25 (1.75–2.89) | 68 (6.9) | 4 (4.5) | 0.508 | — |
complete placenta previa | 58 (2.2) | 53 (1.0) | <0.001 | 2.61 (1.78–3.83) | 44 (2.7) | 53 (1.0) | <0.001 | 3.09 (2.05–4.66) | 14 (1.4) | 0 | — | — |
partial placenta previa | 12 (0.5) | 8 (0.2) | 0.016 | 3.39 (1.36–8.46) | 10 (0.6) | 7 (0.1) | 0.002 | 5.15 (1.92–13.82) | 2 (0.2) | 1 (1.1) | 0.229 | — |
marginal placenta previa | 115 (4.4) | 118 (2.2) | <0.001 | 1.85 (1.42–2.41) | 63 (3.8) | 115 (2.2) | 0.001 | 1.60 (1.17–2.19) | 52 (5.3) | 3 (3.4) | 0.616 | — |
Placental abruption | 40 (1.5) | 16 (0.3) | <0.001 | 5.06 (2.83–9.06) | 21 (1.3) | 15 (0.3) | <0.001 | 4.43 (2.28–8.61) | 19 (1.9) | 1 (1.1) | 1 | — |
pPROM | 258 (9.8) | 176 (3.3) | <0.001 | 3.05 (2.48–3.74) | 85 (5.1) | 161 (3.1) | <0.001 | 1.68 (1.27–2.22) | 173 (17.6) | 15 (16.6) | 1 | — |
Abnormal placental cord insertion | 105 (4.0) | 167 (3.2) | 0.067 | 1.37 (1.06–1.76) | 69 (4.2) | 163 (3.1) | 0.051 | 1.40 (1.05–1.87) | 36 (3.7) | 4 (4.5) | 0.568 | — |
Placental adherence | 197 (7.5) | 173 (3.3) | <0.001 | 2.37 (1.90–2.95) | 115 (6.9) | 168 (3.2) | <0.001 | 2.21 (1.71–2.84) | 82 (8.4) | 5 (5.6) | 0.541 | — |
Postpartum haemorrhage | 197 (7.5) | 155 (2.9) | <0.001 | 2.72 (2.18–3.41) | 82 (4.9) | 151 (2.9) | <0.001 | 1.74 (1.30–2.32) | 115 (11.7) | 4 (4.5) | 0.025 | 2.819 (1.02–7.83) |
Polyhydramnios | 60 (2.3) | 73 (1.4) | 0.005 | 1.79 (1.26–2.53) | 36 (2.2) | 71 (1.4) | 0.03 | 1.65 (1.09–2.50) | 24 (2.4) | 2 (2.3) | 1 | — |
Oligohydramnios | 127 (4.8) | 344 (6.5) | 0.002 | 0.67 (0.54–0.83) | 116 (7.0) | 342 (6.6) | 0.572 | — | 11 (1.1) | 2 (2.3) | 0.295 | — |
