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Figure 2

From: Bone marrow-derived macrophages distinct from tissue-resident macrophages play a pivotal role in Concanavalin A-induced murine liver injury via CCR9 axis

Figure 2

Splenic reservoir monocytes are not essential to induce hepatic injury.

Mice were intravenously injected with Con A on Day14 after splenectomy or sham operation. (a) Left: Representative CD11b and CCR9 staining on total isolated mononuclear cells (upper), and CCR9 histogram on CD11b+ gated cells (lower) from Sham + PBS, Sham + Con A, and Splenectomy + Con A treated mice. Right: Percentage of CCR9+ cells in CD11b+ cells. Data show mean ± SEM (n = 3–5). (b) Serum ALT levels of mice in indicated groups. Data show mean ± SEM (n = 3–5). *p < 0.05, **p < 0.01. n.s.: not significant.

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