Figure 3 | Scientific Reports

Figure 3

From: Bone marrow-derived macrophages distinct from tissue-resident macrophages play a pivotal role in Concanavalin A-induced murine liver injury via CCR9 axis

Figure 3

BM-derived macrophages are indispensable during the course of Con A-induced acute liver injury.

Mice were irradiated to total body (TBI) or irradiated with lead shield over a liver (shield), and further injected with Con A on Day7. (a) Methodological scheme to establish TBI and liver-shielded mice. (b) Absolute numbers of hepatic mononuclear cells (left) and femur-derived BM cells (right) before Con A injection. Data show mean ± SEM (n = 3–5). (c) Left: Representative CD11b and CCR9 staining on isolated hepatic mononuclear cells of mice in indicted group 12 hours after Con A injection. Right: Percentage of CCR9+ cells in CD11b+ cells. (d) Serum ALT levels of mice in indicated groups. Data show mean ± SEM (n = 4). *p < 0.05, **p < 0.01. n.s.: not significant.

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