Table 4 Effect of melatonin on in vitro maturation of GV oocytes.

From: Melatonin improves age-induced fertility decline and attenuates ovarian mitochondrial oxidative stress in mice

Length of treatment (mo)

Groups

No. of mice examined

No. of oocytes cultured

Maturation stage examined in 16–18 h of culture (%)

GV

MI

MII

6

Vehicle

13

395

34 (8.6)

21 (5.3)

340 (86.1)

Melatonin

13

404

32 (7.9)

24 (6.1)

350 (86.6)

12

Vehicle

21

366

41 (11.2)

33 (9.0)

301 (79.8)

Melatonin

17

390

36 (9.7)

27 (6.9)*

339 (83.4)*

  1. *P < 0.05, **P < 0.01 versus vehicle; χ2 test was used.