Table 2 Summary of associations between 3 SNPs in SCN10A and the risk of AF.

From: The rs6771157 C/G polymorphism in SCN10A is associated with the risk of atrial fibrillation in a Chinese Han population

SNP

Position

Minor/major

Genotype distributiona

MAF

Crude ESb

Adjusted ESc

Cases

Controls

Cases

Controls

P HWE

OR(95% CI)

P Value

OR(95% CI)

P Value

P FDR d

rs9827941

38811463

A/T

80/444/626

87/425/622

0.26

0.26

0.23

0.99(0.87–1.13)

0.909

1.01(0.88–1.16)

0.910

0.910

rs7630989

38768944

G/A

63/360/727

59/371/720

0.21

0.21

0.22

0.99(0.87–1.14)

0.916

1.03(0.89–1.19)

0.741

0.910

rs6771157

38738867

C/G

255/581/314

217/535/398

0.47

0.42

0.12

1.24(1.10–1.39)

3.48 × 10βˆ’4

1.20(1.06–1.36)

0.003

0.010

  1. SNP, single nucleotide polymorphism; MAF, minor allele frequency; PHWE, P values for Hardy–Weinberg equilibrium tests in the control group; ES effect size; OR odds ratio; CI confidence interval.
  2. aGenotype distribution for the minor allele/heterozygous/homozygous.
  3. bES were derived from logistic regression analysis in the additive model for unadjustment of any covariants.
  4. cES were derived from logistic regression analysis in the additive model for adjustment of age, gender, hypertension, diabetes and coronary artery disease.
  5. dMultiple comparisons P values for false discovery rate.
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