Figure 2
From: Whole Chromosome Instability induces senescence and promotes SASP
Proliferation of HPF is impaired upon BUB1 or SMC1A knockdown.
(a) Growth curve of EV, BUB1 or SMC1-depleted and SEN cultures as assessed by number of PDs. (b) Quantification of percentage of MKI67 positively stained cells per cell line. (c) Representative IF images for the proliferation marker MKI67 (red) in EV, SEN, BUB1 and SMC1A-depleted cells. (*) Indicates significant differences (p < 0.05) from EV cells tested by One-way ANOVA. Data are expressed as mean ± SD (n = 3).
