Figure 3 | Scientific Reports

Figure 3

From: Bone marrow-derived and peritoneal macrophages have different inflammatory response to oxLDL and M1/M2 marker expression – implications for atherosclerosis research

Figure 3

No clear M1/M2 gene expression profile in BMDMs and PEMs.

(a–c) mRNA levels (2−ΔCT) of M2 markers (a), M1 markers (b), or genes related to lipid metabolism (c) in PEMs depicted as a function of mRNA levels (2−ΔCT) in BMDMs (n = 3 mice for BMDMs and 3 pools of 4–5 mice for PEMs). Each grey circle represents expression of a given gene in macrophages (Mø, 0 μg/mL oxLDL 24 h), whereas each square represents expression of a given gene in foam cells (Fc, 25 μg/mL oxLDL 24 h) as measured by PCR array analyses. The full line indicate genes, with similar expression levels in both cell types, while data points placed above or below the dotted lines are more than 2 fold up- or down-regulated, respectively, in PEMs as compared to BMDMS. The specific genes of interest, their fold change, and statistics can be found in Table 1.

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