Figure 4

Amelioration of AKI in AIM felinised mouse by rAIM.

(a) Survival of AIM felinised (n = 4, black dotted line) and mouse rAIM-injected AIM felinised mice (n = 7, red solid line) after IR (Kaplan-Meier method). ▼; rAIM (mouse; 1 mg) injected. P: statistical significance between each type of mouse was calculated by using the log-rank test. (b) The Cre levels on the indicated days after IR. Black squares, AIM felinised mice (n = 4); red squares, rAIM (mouse; 1 mg)-injected AIM felinised mice (n = 7). Male mice at 8–10 weeks of age were used. (c) The ATN score in the kidney of IR-treated AIM felinised mice (n = 3) and rAIM-injected AIM felinised mice (n = 3) on day 3 after IR. (d) Accumulation of AIM on intraluminal debris in rAIM-injected AIM felinised mice at day 1 after IR. Signals were visualised by HRP/DAB. Scale bars, 50 μm.