Figure 5
Metabolic pathways linking cystathionine, glutathione and methionine metabolism.
(a) Comparison of ΔegtA26933 and ATCC26933 under basal conditions showing an absence of cystathionine γ-synthase, which converts cysteine to cystathionine. This could be due to a switch towards increased glutathione production. (b) Comparison of ΔegtA26933 and ATCC26933 upon addition of 3 mM H2O2 shows an increased abundance of cystathionine β-synthase, which converts cystathionine to homocysteine. This would result in increased production of SAM, which is required for EGT biosynthesis.
