Figure 3
From: Longer latency of sensory response to intravenous odor injection predicts olfactory neural disorder
Individual glomeruli show distinct neural response patterns but similar onset times in response to prosultiamine (PST) stimulation.
(a) Image of the olfactory bulb (OB) dorsal surface following PST administration. Glomeruli g1–g6 are responsive. Scale bar, 500 μm. (b) PST-induced spH signals from glomerulus g1. The onset latency was determined as the first 5 s bin with significantly increased ∆F/F0 compared with that of the bin immediately before PST administration (left, magenta arrow, onset time). The duration was determined by the interval from the onset time to 50% decay from peak (right). (c) PST-induced synaptopHluorin signals from individual glomeruli (g2 to g6; magenta open rectangles, onset time; magenta filled rectangles, duration). (d) Summary of onset latency and duration for each glomerulus shown in (a) (g1–g6). Diamond, onset time; square, duration. (e) Summary of onset latency and duration for 140 glomeruli (28 olfactory bulbs, 17 mice). Diamond, onset latency; square, duration.
