Figure 1

SF exposure increases food intake over time, which returns to baseline upon discontinuation of SF (a), along with increased VWAT mass (b), systemic (c) and VWAT insulin resistance (d). Representative FACS plots showing the gating strategies used for macrophages (e), neutrophils (f), and M1 macrophages (g). After 4 weeks of SF exposures, increases in VWAT macrophages (h), neutrophils (i), and M1 macrophages (j) emerged, and returned to within CTL values in SF 2R mice.