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Figure 1

From: Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability

Figure 1

Characterization of PHH and HepaRG spheroids.

(A) Morphology of PHH and HepaRG spheroids. (B,C) Immunohistochemical analysis for MRP2 and BSEP protein expression in PHH and HepaRG spheroids at day 16 and 13 respectively with or without 8 day exposure to a mixture of BAs. Quantification of the surface expression of the BA transporters was performed using CellProfiler software. *p < 0.05. All scale bars = 100 μm.

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