Figure 6 | Scientific Reports

Figure 6

From: Smooth muscle cell-specific Tgfbr1 deficiency promotes aortic aneurysm formation by stimulating multiple signaling events

Figure 6

Inhibition of ERK phosphorylation effectively protects Tgfbr1iko aortas from aneurysmal degeneration.

(A) Changes in the diameter of RDEA-119-treated (RDEA, n = 7) or placebo-treated (Pla, n = 8) Tgfbr1iko aortas in 14 days. Data were analyzed using the unpaired t-test. (B) Incidence of intimal/medial tears in Tgfbr1iko aortas that were treated with RDEA-119 or placebo. Data were analyzed using Fisher’s exact tests. ND = not detected. (C) En face microscopy of the luminal surface of RDEA-119- or placebo-treated ATA segments. Focal intimal/medial tears were stained blue (indicated by red arrows), due to extravasation of Evans Blue, which was injected into mice prior to sample collection.

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