Figure 1
From: Alterations of the Host Microbiome Affect Behavioral Responses to Cocaine
Knockdown of intestinal bacteria using non-absorbable antibiotics.
(a) Schematic representation of the experimental procedure. (b) Fluid intake did not differ between control (H2O) and antibiotic-treated (Abx) groups (n = 32 H2O, 39 Abx). (c) Mean body weight did not differ between groups and was not affected by antibiotic treatment (n = 32 H2O, 39 Abx). (d) Gross morphology of the cecum from untreated (left) and antibiotic-treated (right) mice with ruler shown for scale. (e) Quantitative measurement of cecal weights between control and antibiotic-treated mice demonstrates a marked increase in antibiotic-treated animals (***p < 0.0001; n = 24 H2O, 28 Abx). (f) qPCR analysis of total bacterial load between the two conditions demonstrates a decrease in bacterial load in antibiotic-treated mice (***p < 0.0001; n = 16 H2O, 14 Abx).
