Figure 1

Puerarin prolonged APD of rat ventricular myocytes.

(a) Puerarin at the concentrations of 100 μM significantly prolonged APD of rat ventricles; whereas isoproterenol at the concentrations of 10 nM significantly shortened APD of rat ventricles, in comparing with control. (b) Puerarin (100 μM) significantly offseted the reduced effect of isoproterenol (10 nM) and extended APD of rat ventricles at the 50% and 90% measurement points by respectively. *P < 0.01, **P < 0.001 versus control. n = 5 each point. (c) Puerarin at the concentrations of 10 μM, 100 μM, 1 mM, 10 mM, 100 mM and 200 mM extended APD of rat ventricles, in comparing with control. The statistical results were shown in table1. (d) The molecular structural formula of puerarin.